Douglas CDMO has world-class expertise in the development and manufacturing of softgel capsules and medicine fill.
Decades of softgel excellence
Douglas CDMO has extensive expertise in the development and manufacturing of softgel capsules, having developed approximately one-third of the pharmaceutical softgels available in the EU and U.S. markets.
With decades of experience, Douglas CDMO has excelled in the development, manufacturing, and commercialization of softgel capsules by maintaining high standards of safety and efficacy, leveraging technical expertise, and advanced technological capabilities
Encapsulate your formula within a softgel
Soft gelatin capsules are a delivery platform, containing an inner fill with an API. They lend themselves to various applications, including over-the-counter medications, dietary supplements, vitamins, nutraceuticals, and prescription pharmaceuticals. They are particularly suitable for liquid or semi-solid formulations, and commonly used for oil-based or lipid-soluble drugs.
The benefits of softgel include:
- Enhanced absorption rate, and overall bioavailability of the drug to ensure the lowest effective dose is used to achieve its full therapeutic effect.
- Addressing solubility issues.
- Protection of ingredients from exposure to light, air and moisture.
- Easier to swallow than hardshell capsules and tablets.
- A consistent and precise dose of the active ingredient.
- Enhanced shelf life.
The complex nature of softgel manufacturing, involving specialized equipment and proprietary formulations, also presents significant barriers to their generic production. This complexity ensures the preservation of product quality and efficacy, safeguarding your investment.
Improved bioavailability
Softgel capsules stand out for their remarkable capability to enhance the bioavailability of certain compounds, guaranteeing optimal delivery of the active ingredient to its target site within the body. This enhanced bioavailability not only boosts therapeutic effectiveness but also maintains steady drug levels and may even reduce necessary dosages, ultimately leading to superior patient outcomes.
Abuse deterrent
Abuse-deterrent formulations target the known or expected routes of abuse, such as crushing to snort or dissolving to inject the drug substance. The field of abuse deterrence is emerging, with formulation technologies and evaluation methods evolving. Douglas CDMO has experience in developing these formulations and has laboratory partnerships with specialist capability to evaluate abuse deterrent features of proprietary dosage forms.
Why choose Douglas for your softgel contract development and manufacturing?
Douglas has over 30 years of experience in handling high-potency small molecule formulations with successful registrations. We have the capability and procedures to manage light-sensitive retinoids, hormones, cytotoxics, and immunosuppressants. Our high success rate in developing complex softgels and securing approvals in the US and Europe underscores our expertise.
Commercial manufacturing
Douglas CDMO has two manufacturing sites, including state-of-the-art softgel manufacturing equipment.
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